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Evaluating the Probability of CRISPR-based Gene Drive Contaminating Another Species

By Virginie Courtier-Orgogozo, Antoine Danchin, Pierre-Henri Gouyon, Christophe Bo√ęte

Posted 19 Sep 2019
bioRxiv DOI: 10.1101/776609 (published DOI: 10.1111/eva.12939)

The probability D that a given CRISPR-based gene drive element contaminates another, non-target species can be estimated by the following Drive Risk Assessment Quantitative Estimate (DRAQUE) Equation: We discuss and estimate each of the seven parameters of the equation, with particular emphasis on possible transfers within insects, and between rodents and humans. We conclude from current data that the probability of a gene drive cassette to contaminate another species is not insignificant. We propose strategies to reduce this risk and call for more work on estimating all the parameters of the formula. * CRISPR : Clustered Regularly Interspaced Short Palindromic Repeats DRAQUE : Drive Risk Assessment Quantitative Estimate HGT : horizontal gene transfer HTT : horizontal transfer of transposable element TE : transposable element

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