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Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti . The w Mel Wolbachia strain has previously been trialed in open releases of Ae. aegypti ; however the w AlbB strain has been shown to maintain higher density than w Mel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying w AlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites, or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The w AlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

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