Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,900 bioRxiv papers from 321,596 authors.

Objective: Mismatch negativity (MMN) is an auditory event-related potential (ERP) used to study schizophrenia and psychosis risk. MMN reliability from a multisite, traveling subjects study was compared using different ERP referencing, averaging, and scoring techniques. Methods: Reliability of frequency, duration, and double (frequency+duration) MMN was determined from eight traveling subjects, tested on two occasions at eight EEG laboratory sites. Deviant-specific variance components were estimated for MMN peak amplitude and latency measures using different ERP processing methods. Generalizability (G) coefficients were calculated using two-facet (site, occasion), fully-crossed models and single-facet (occasion) models within each laboratory to assess MMN reliability. Results: G-coefficients calculated from two-facet models indicated fair (0.4<G<=0.6) duration MMN reliability at electrode Fz, but poor (G<0.4) double and frequency MMN reliability. Single-facet G-coefficients averaged across laboratory resulted in improved reliability (G>0.5). Reliability of MMN amplitude was greater than latency, and reliability with mastoid referencing significantly outperformed nose-referencing. Conclusions: EEG preprocessing methods have a significant impact on the reliability of MMN amplitude. Within site MMN reliability can be excellent, consistent with prior single site studies. Significance: With standardized data collection and ERP processing, MMN can be reliably obtained in multisite studies, providing larger samples sizes within rare patient groups.

Download data

  • Downloaded 99 times
  • Download rankings, all-time:
    • Site-wide: 69,726 out of 73,896
    • In neuroscience: 12,527 out of 13,293
  • Year to date:
    • Site-wide: 29,157 out of 73,896
  • Since beginning of last month:
    • Site-wide: 29,157 out of 73,896

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)