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Reliability of Mismatch Negativity Event-Related Potentials in a Multisite, Traveling Subjects Study
Ricardo E Carrion,
Holly K Hamilton,
Gregory A Light,
Carrie E Bearden,
Kristin S. Cadenhead,
Tyrone D. Cannon,
Barbara A. Cornblatt,
Thomas H. McGlashan,
Diana O Perkins,
Larry J Seidman,
Elaine F. Walker,
Scott W. Woods,
Daniel H Mathalon
Posted 18 Sep 2019
bioRxiv DOI: 10.1101/768408
Posted 18 Sep 2019
Objective: Mismatch negativity (MMN) is an auditory event-related potential (ERP) used to study schizophrenia and psychosis risk. MMN reliability from a multisite, traveling subjects study was compared using different ERP referencing, averaging, and scoring techniques. Methods: Reliability of frequency, duration, and double (frequency+duration) MMN was determined from eight traveling subjects, tested on two occasions at eight EEG laboratory sites. Deviant-specific variance components were estimated for MMN peak amplitude and latency measures using different ERP processing methods. Generalizability (G) coefficients were calculated using two-facet (site, occasion), fully-crossed models and single-facet (occasion) models within each laboratory to assess MMN reliability. Results: G-coefficients calculated from two-facet models indicated fair (0.4<G<=0.6) duration MMN reliability at electrode Fz, but poor (G<0.4) double and frequency MMN reliability. Single-facet G-coefficients averaged across laboratory resulted in improved reliability (G>0.5). Reliability of MMN amplitude was greater than latency, and reliability with mastoid referencing significantly outperformed nose-referencing. Conclusions: EEG preprocessing methods have a significant impact on the reliability of MMN amplitude. Within site MMN reliability can be excellent, consistent with prior single site studies. Significance: With standardized data collection and ERP processing, MMN can be reliably obtained in multisite studies, providing larger samples sizes within rare patient groups.
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