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Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells

By Veronica Davé, E. Fabian Cardozo-Ojeda, Florian Mair, Jami Erickson, Amanda S. Woodward-Davis, Amanda Koehne, Andrew Soerens, Julie Czartoski, Candice Teague, Nicole Potchen, Susanne Oberle, Dietmar Zehn, Joshua T Schiffer, Jennifer M. Lund, Martin Prlic

Posted 14 Sep 2019
bioRxiv DOI: 10.1101/769711

Tissue-resident memory CD8 T cells (CD8 TRM) are critical for maintaining barrier immunity. CD8 TRM have been mainly studied in the skin and gut with recent studies suggesting that the signals that control tissue-residence and phenotype are highly tissue-dependent. We examined the T cell compartment in healthy human cervicovaginal tissue (CVT) and found that most CD8 T cells were granzyme B+ and TCF-1-. To address if this phenotype is driven by CVT tissue-residence, we used a mouse model to control for environmental factors. Using localized and systemic infection models, we found that CD8 TRM in the mouse CVT gradually acquired a granzyme B+, TCF-1- phenotype as seen in human CVT. In contrast to CD8 TRM in the gut, these CD8 TRM were not stably maintained regardless of the initial infection route, which led to reductions in local immunity. Our data show that residence in the CVT is sufficient to progressively shape the size and function of its CD8 TRM compartment. ### Competing Interest Statement The authors have declared no competing interest.

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