Methylome-Wide Association Study Of Central Adiposity Implicates Genes Involved In Immune And Endocrine Systems
Anne E Justice,
Phillip E Melton,
Megan L Grove,
Eric A Whitsel,
L. Adrienne Cupples,
James D Stewart,
Lawrence J. Beilin,
Annie Green Howard,
Kari E. North
Posted 12 Sep 2019
bioRxiv DOI: 10.1101/766832 (published DOI: 10.2217/epi-2019-0276)
Posted 12 Sep 2019
We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio, and waist-to-height ratio adjusted for body mass index, in 2684 African American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated Cytosine-phosphate-Guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined N=5743) and generalized associations in adolescents from The Raine Study (N=820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and 2 in adolescents, including CpG site associations near TXNIP , ADCY7 , SREBF1 , and RAP1GAP2 that had not previously been associated with obesity-related traits.
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