Methylome-Wide Association Study Of Central Adiposity Implicates Genes Involved In Immune And Endocrine Systems
Anne E Justice,
Phillip E Melton,
Megan L Grove,
Eric A Whitsel,
L. Adrienne Cupples,
James D Stewart,
Lawrence J. Beilin,
Annie Green Howard,
Kari E. North
Posted 12 Sep 2019
bioRxiv DOI: 10.1101/766832 (published DOI: 10.2217/epi-2019-0276)
Posted 12 Sep 2019
We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio, and waist-to-height ratio adjusted for body mass index, in 2684 African American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated Cytosine-phosphate-Guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined N=5743) and generalized associations in adolescents from The Raine Study (N=820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and 2 in adolescents, including CpG site associations near TXNIP , ADCY7 , SREBF1 , and RAP1GAP2 that had not previously been associated with obesity-related traits.
- Downloaded 379 times
- Download rankings, all-time:
- Site-wide: 62,396
- In genomics: 4,554
- Year to date:
- Site-wide: 81,098
- Since beginning of last month:
- Site-wide: 44,175
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!