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Integrated clonal analysis reveals circulating tumor DNA in urine and plasma of glioma patients

By Florent Mouliere, Katrin Heider, Christopher G. Smith, Jing Su, Mareike Thompson, James Morris, Jonathan CM Wan, Dineika Chandrananda, James Hadfield, Marta Grezlak, Irena Hudecova, Wendy Cooper, Davina Gale, Matt Eldridge, Colin Watts, Kevin Brindle, Nitzan Rosenfeld, Richard Mair

Posted 11 Sep 2019
bioRxiv DOI: 10.1101/758441

Glioma-derived cell-free tumor DNA is challenging to detect using standard liquid biopsy techniques as its levels in body fluids are very low, similar to those in patients with early stage carcinomas. By sequencing cell-free DNA across thousands of clonal and private mutations identified individually in each patient's tumor we detected tumor-derived DNA in plasma (10/12, 83%) and urine samples (8/11, 72%) from the majority (7/8, 87.5%) of glioma patients tested.

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