KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.
Brendan J. McMorran,
Simon J. Foote,
Posted 08 Sep 2017
bioRxiv DOI: 10.1101/186262 (published DOI: 10.1038/s41598-019-42782-x)
Posted 08 Sep 2017
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1M935K/M935K mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ T cells and TNF-α response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria.
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