Rxivist logo

Lineage-specific control of convergent differentiation by a Forkhead repressor

By Karolina Mizeracka, Julia M Rogers, Jonathan D Rumley, Shai Shaham, Martha L. Bulyk, John I. Murray, Maxwell G Heiman

Posted 05 Sep 2019
bioRxiv DOI: 10.1101/758508

During convergent differentiation, multiple developmental lineages produce a highly similar or identical cell type. However, the molecular players that drive convergent differentiation are not known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification of cells related by lineage rather than by cell type. Specification defects correlate with UNC-130:DNA binding, and UNC-130 can be functionally replaced by its human homolog, the neural crest lineage determinant FoxD3. We propose that, in contrast to terminal selectors that activate cell-type specific transcriptional programs in terminally differentiating cells, UNC-130 acts earlier to enable molecularly distinct progenitors to produce equivalent cell types. These findings provide evidence that convergent differentiation involves distinct transcriptional paths leading to the same cell type.

Download data

  • Downloaded 623 times
  • Download rankings, all-time:
    • Site-wide: 35,835
    • In developmental biology: 813
  • Year to date:
    • Site-wide: 31,284
  • Since beginning of last month:
    • Site-wide: 7,700

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)