The Setaria viridis genome and diversity panel enables discovery of a novel domestication gene
By
Sujan Mamidi,
Adam Healey,
Pu Huang,
Jane Grimwood,
Jerry Jenkins,
Kerrie W. Barry,
Avinash Sreedasyam,
Shengqiang Shu,
John T. Lovell,
Maximilian Feldman,
Jinxia Wu,
Yunqing Yu,
Cindy Chen,
Jenifer Johnson,
Hitoshi Sakakibara,
Takatoshi Kiba,
Tetsuya Sakurai,
Rachel Tavares,
Dmitri A. Nusinow,
Ivan Baxter,
Jeremy Schmutz,
Thomas P. Brutnell,
Elizabeth A. Kellogg
Posted 24 Aug 2019
bioRxiv DOI: 10.1101/744557
Diverse wild and weedy crop relatives hold genetic variants underlying key evolutionary innovations of crops under domestication. Here, we provide genome resources and probe the genetic basis of domestication traits in green millet (Setaria viridis), a close wild relative of foxtail millet (S. italica). Specifically, we develop and exploit a platinum-quality genome assembly and de novo assemblies for 598 wild accessions to identify loci underlying a) response to climate, b) a key loss-of-shattering trait that permits mechanical harvest, and c) leaf angle, a major predictor of yield in many grass crops. With CRISPR-Cas9 genome editing, we validated Less Shattering1 (SvLES1) as a novel gene for seed shattering, which is rendered non-functional via a retrotransposon insertion in SiLes1, the domesticated loss-of-shattering allele of S. italica. Together these results and resources project S. viridis as a key model species for complex trait dissection and biotechnological improvement of panicoid crops. ### Competing Interest Statement The authors have declared no competing interest.
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