Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae
David W Cleary,
Vanessa T Devine,
Denise E Morris,
Karen L Osman,
Rebecca A. Gladstone,
Stephen D. Bentley,
Saul N Faust,
Stuart C Clarke
Posted 04 Dec 2017
bioRxiv DOI: 10.1101/228791 (published DOI: 10.1099/mgen.0.000209)
Posted 04 Dec 2017
Between 2008/09 and 2012/13 the molecular epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage in children <5 years of age was determined; a period that included pneumococcal conjugate vaccine (PCV) 13 introduction. Significantly increased carriage in post-PCV13 years was observed and lineage-specific associations with S. pneumoniae were observed before and after PCV13 introduction. NTHi were characterised into eleven discrete, temporally stable lineages, congruent with current knowledge regarding the clonality of NTHi. This increase could not be linked to the expansion of a particular clone and demonstrates different dynamics to before PCV13 implementation during which time NTHi co-carried with vaccine serotype pneumococci.
- Downloaded 405 times
- Download rankings, all-time:
- Site-wide: 94,255
- In microbiology: 6,402
- Year to date:
- Site-wide: None
- Since beginning of last month:
- Site-wide: 154,793
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!