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Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae

By David W Cleary, Vanessa T Devine, Denise E Morris, Karen L Osman, Rebecca A. Gladstone, Stephen D. Bentley, Saul N Faust, Stuart C Clarke

Posted 04 Dec 2017
bioRxiv DOI: 10.1101/228791 (published DOI: 10.1099/mgen.0.000209)

Between 2008/09 and 2012/13 the molecular epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage in children <5 years of age was determined; a period that included pneumococcal conjugate vaccine (PCV) 13 introduction. Significantly increased carriage in post-PCV13 years was observed and lineage-specific associations with S. pneumoniae were observed before and after PCV13 introduction. NTHi were characterised into eleven discrete, temporally stable lineages, congruent with current knowledge regarding the clonality of NTHi. This increase could not be linked to the expansion of a particular clone and demonstrates different dynamics to before PCV13 implementation during which time NTHi co-carried with vaccine serotype pneumococci.

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