Rxivist logo

STABILITY ANALYSIS OF A BULK-SURFACE REACTION MODEL FOR MEMBRANE-PROTEIN CLUSTERING

By Lucas M. Stolerman, Michael Getz, Stefan G. Llewellyn Smith, Michael Holst, Padmini Rangamani

Posted 15 Aug 2019
bioRxiv DOI: 10.1101/736165 (published DOI: 10.1007/s11538-020-00703-4)

Protein aggregation on the plasma membrane (PM) is of critical importance to many cellular processes such as cell adhesion, endocytosis, fibrillar conformation, and vesicle transport. Lateral diffusion of protein aggregates or clusters on the surface of the PM plays an important role in governing their heterogeneous surface distribution. However, the stability behavior of the surface distribution of protein aggregates remains poorly understood. Therefore, understanding the spatial patterns that can emerge on the PM solely through protein-protein interaction, lateral diffusion, and feedback is an important step towards a complete description of the mechanisms behind protein clustering on the cell surface. In this work, we investigate the pattern formation of a reaction-diffusion model that describes the dynamics of a system of ligand-receptor complexes. The purely diffusive ligand in the cytosol can bind receptors in the PM, and the resultant ligand-receptor complexes not only diffuse laterally but can also form clusters resulting in different oligomers. Finally, the largest oligomers recruit ligands from the cytosol in a positive feedback. From a methodological viewpoint, we provide theoretical estimates for diffusion-driven instabilities of the protein aggregates based on the Turing mechanism. Our main result is a threshold phenomenon, in which a sufficiently high recruitment of ligands promotes the input of new monomeric components and consequently drives the formation of a single-patch spatially heterogeneous steady-state.

Download data

  • Downloaded 226 times
  • Download rankings, all-time:
    • Site-wide: 64,415 out of 88,857
    • In cell biology: 3,289 out of 4,553
  • Year to date:
    • Site-wide: 57,897 out of 88,857
  • Since beginning of last month:
    • Site-wide: 66,589 out of 88,857

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News