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Constraints and limitations on decoding positional information: the Bicoid case-study

By Huy Tran, Aleksandra M Walczak, Nathalie Dostatni

Posted 08 Aug 2019
bioRxiv DOI: 10.1101/728840

The regulation of expression of the hunchback promoter by the maternal Bicoid gradient has been studied as a model system in development for many years. Yet, at the level of quantitative agreement between data and theoretical models, even the first step of this regulation, transcription, continues to be challenging. This situation is slowly progressing, thanks to quantitative live-imaging techniques coupled to advanced statistical data analysis and modelling. Here we outline the current state our knowledge of this apparently 'simple' step, highlighting the newly appreciated role of bursty transcription dynamics and its regulation.

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