Rxivist logo

Constraints and limitations on the transcriptional response downstream of the Bicoid morphogen gradient

By Huy Tran, Aleksandra M Walczak, Nathalie Dostatni

Posted 08 Aug 2019
bioRxiv DOI: 10.1101/728840

The regulation of the hunchback promoter expression by the maternal Bicoid gradient has been studied as a model system in development for many years. Yet, at the level of quantitative agreement between data and theoretical models, even the first step of this regulation, transcription, continues to be challenging. This situation is slowly progressing, thanks to quantitative live-imaging techniques coupled to advanced statistical data analysis and modelling. Here we outline the current state of our knowledge of this apparently “simple” step, highlighting the newly appreciated role of bursty transcription dynamics and its regulation.

Download data

  • Downloaded 429 times
  • Download rankings, all-time:
    • Site-wide: 34,696 out of 83,434
    • In developmental biology: 980 out of 2,483
  • Year to date:
    • Site-wide: 15,980 out of 83,434
  • Since beginning of last month:
    • Site-wide: 21,364 out of 83,434

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)