Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,506 bioRxiv papers from 264,779 authors.

Selection against expression noise explains the origin of the hourglass pattern of Evo-Devo

By Jialin Liu, Michael Frochaux, Vincent Gardeux, Bart Deplancke, Marc Robinson-Rechavi

Posted 13 Jul 2019
bioRxiv DOI: 10.1101/700997

The evolution of embryological development has long been characterized by deep conservation. Both morphological and transcriptomic surveys have proposed a 'hourglass' model of Evo-Devo. A stage in mid-embryonic development, the phylotypic stage, is highly conserved among species within the same phylum. However, the reason for this phylotypic stage is still elusive. Here we hypothesize that the phylotypic stage might be characterized by selection for robustness to noise and environmental perturbations. This could lead to mutational robustness, thus evolutionary conservation of expression and the hourglass pattern. To test this, we quantified expression variability of single embryo transcriptomes throughout fly Drosophila melanogaster embryogenesis. We found that indeed expression variability is lower at extended germband, the phylotypic stage. We explain this pattern by stronger histone modification mediated transcriptional noise control at this stage. In addition, we find evidence that histone modifications can also contribute to mutational robustness in regulatory elements. Thus, the robustness to noise does indeed contributes to robustness of gene expression to genetic variations, and to the conserved phylotypic stage.

Download data

  • Downloaded 292 times
  • Download rankings, all-time:
    • Site-wide: 30,587 out of 57,506
    • In developmental biology: 872 out of 1,702
  • Year to date:
    • Site-wide: 8,618 out of 57,506
  • Since beginning of last month:
    • Site-wide: 616 out of 57,506

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News