Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,822 bioRxiv papers from 266,142 authors.
22q11.2 Deletion Syndrome (22q11.2DS) is the strongest known molecular risk factor for schizophrenia. Scalp recorded electrical brain responses to auditory stimuli have been studied extensively in schizophrenia and described as potential biomarkers of vulnerability to psychosis. Here we sought to understand whether these brain responses, along with cognitive factors associated with schizophrenia, might aid in differentiating individuals with 22q11.2DS as a function of psychotic symptoms, and ultimately serve as early signals of higher risk for schizophrenia in this population. Using a passive duration oddball paradigm and high-density electrophysiology, we tested basic auditory processing in a group of 21 adolescents and adults with 22q11.2DS with varying degrees of psychotic symptomatology and neurotypical age-matched controls. We examined whether the N1 and mismatch negativity (MMN), typically reduced in idiopathic schizophrenia, significantly correlated with psychotic symptomatology, IQ, and working memory. At the group level of analysis, individuals diagnosed with 22q11.2DS presented increased N1 responses and similar MMN responses to their neurotypical peers. Correlation analyses revealed that poorer working memory was associated with decreased MMN amplitude, and that this was largely driven by the 22q11.2DS group. We suggest that enhanced auditory sensory processing is general to 22q11.2DS, whilst poorer working memory is related to vulnerability for psychosis and smaller MMNs in 22q11.2DS.
- Downloaded 70 times
- Download rankings, all-time:
- Site-wide: 55,117 out of 57,822
- In neuroscience: 9,702 out of 10,200
- Year to date:
- Site-wide: 42,626 out of 57,822
- Since beginning of last month:
- Site-wide: 7,055 out of 57,822
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!