Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,822 bioRxiv papers from 266,142 authors.

Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 Deletion Syndrome

By Ana A Francisco, John J. Foxe, Douwe J Horsthuis, Danielle DeMaio, Sophie Molholm

Posted 09 Jul 2019
bioRxiv DOI: 10.1101/696021

22q11.2 Deletion Syndrome (22q11.2DS) is the strongest known molecular risk factor for schizophrenia. Scalp recorded electrical brain responses to auditory stimuli have been studied extensively in schizophrenia and described as potential biomarkers of vulnerability to psychosis. Here we sought to understand whether these brain responses, along with cognitive factors associated with schizophrenia, might aid in differentiating individuals with 22q11.2DS as a function of psychotic symptoms, and ultimately serve as early signals of higher risk for schizophrenia in this population. Using a passive duration oddball paradigm and high-density electrophysiology, we tested basic auditory processing in a group of 21 adolescents and adults with 22q11.2DS with varying degrees of psychotic symptomatology and neurotypical age-matched controls. We examined whether the N1 and mismatch negativity (MMN), typically reduced in idiopathic schizophrenia, significantly correlated with psychotic symptomatology, IQ, and working memory. At the group level of analysis, individuals diagnosed with 22q11.2DS presented increased N1 responses and similar MMN responses to their neurotypical peers. Correlation analyses revealed that poorer working memory was associated with decreased MMN amplitude, and that this was largely driven by the 22q11.2DS group. We suggest that enhanced auditory sensory processing is general to 22q11.2DS, whilst poorer working memory is related to vulnerability for psychosis and smaller MMNs in 22q11.2DS.

Download data

  • Downloaded 70 times
  • Download rankings, all-time:
    • Site-wide: 55,117 out of 57,822
    • In neuroscience: 9,702 out of 10,200
  • Year to date:
    • Site-wide: 42,626 out of 57,822
  • Since beginning of last month:
    • Site-wide: 7,055 out of 57,822

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)