Individual Variation in Control Network Topography Supports Executive Function in Youth
Cedric H Xia,
Graham L Baum,
Raquel E. Gur,
Ruben C. Gur,
Tyler M. Moore,
Desmond J. Oathes,
David R. Roalf,
Russell T. Shinohara,
Daniel H Wolf,
Danielle S. Bassett,
Damien A. Fair,
Theodore D. Satterthwaite
Posted 08 Jul 2019
bioRxiv DOI: 10.1101/694489
Posted 08 Jul 2019
The spatial distribution of large-scale functional networks on the anatomic cortex differs between individuals, and is particularly variable in networks responsible for executive function. However, it remains unknown how this functional topography evolves in development and supports cognition. Capitalizing upon advances in machine learning and a large sample of youth (n=693, ages 8-23y) imaged with 27 minutes of high-quality fMRI data, we delineate how functional topography evolves during youth. We found that the functional topography of association networks is refined with age, allowing accurate prediction of an unseen individual's brain maturity. Furthermore, the cortical representation of executive networks predicts individual differences in executive function. Finally, variability of functional topography is associated with fundamental properties of brain organization including evolutionary expansion, cortical myelination, and cerebral blood flow. Our results emphasize the importance of considering both the plasticity and diversity of functional neuroanatomy during development, and suggest advances in personalized therapeutics.
- Downloaded 848 times
- Download rankings, all-time:
- Site-wide: 12,355 out of 78,097
- In neuroscience: 2,001 out of 13,985
- Year to date:
- Site-wide: 5,405 out of 78,097
- Since beginning of last month:
- Site-wide: 20,135 out of 78,097
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!