Super-enhancers are the clusters of transcriptional enhancers that can drive cell-type-specific gene expression and also crucial in cell identity. Many disease-associated sequence variations are enriched in super-enhancer regions of disease-relevant cell types. Thus, super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance. However, no centralized resource to integrate all these findings is available yet. We developed dbSUPER (http://bioinfo.au.tsinghua.edu.cn/dbsuper/), the first integrated and interactive database of super-enhancers, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease. dbSUPER provides a responsive and user-friendly web interface to facilitate efficient and comprehensive search and browsing. The data can be easily sent to Galaxy instances, GREAT and Cistrome web servers for downstream analysis, and can be visualized in UCSC genome browser while custom tracks added automatically. The data can be downloaded and exported in variety of formats. Further, dbSUPER lists genes associated with the super-enhancers and links to various other databases such as GeneCards, UniProt and Entrez. dbSUPER also provides an overlap analysis tool, to annotate user defined regions. We believe dbSUPER is a valuable resource for the biologists and genetic research communities.
- Downloaded 2,574 times
- Download rankings, all-time:
- Site-wide: 2,553 out of 94,912
- In bioinformatics: 456 out of 8,837
- Year to date:
- Site-wide: 59,816 out of 94,912
- Since beginning of last month:
- Site-wide: 43,549 out of 94,912
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!