Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,960 bioRxiv papers from 321,862 authors.

Quantifying phenotypic variability and fitness in finite microbial populations

By Ethan Levien, Jane Kondev, Ariel Amir

Posted 28 Jun 2019
bioRxiv DOI: 10.1101/680066

In isogenic microbial populations, phenotypic variability is generated by a combination of intrinsic factors, specified by cell physiology, and environmental factors. Here we address the question: how does phenotypic variability of a microbial population affect its fitness? While this question has previously been studied for exponentially growing populations, the situation when the population size is kept fixed has received much less attention. We show that in competition experiments with multiple microbial species, the fitness of the population can be determined from the distribution of phenotypes, provided all variability is due to intrinsic factors. We then explore how robust the relationship between fitness and phenotypic variability is to environmental fluctuations. We find that this relationship breaks down in the presence of environmental fluctuations, and derive a simple formula relating the average fitness of a population to the phenotype distribution and fluctuations in the instantaneous population growth rate. Using published experimental data we demonstrate how our formulas can be used to discriminate between intrinsic and environmental contributions to phenotypic diversity.

Download data

  • Downloaded 658 times
  • Download rankings, all-time:
    • Site-wide: 16,639 out of 74,003
    • In systems biology: 482 out of 2,021
  • Year to date:
    • Site-wide: 10,860 out of 74,003
  • Since beginning of last month:
    • Site-wide: 10,860 out of 74,003

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)