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FASTmC: a suite of predictive models for non-reference-based estimations of DNA methylation

By Adam J Bewick, Brigitte T. Hofmesiter, Kevin Lee, Xiaoyu Zhang, Dave W Hall, Robert J. Schmitz

Posted 20 Oct 2015
bioRxiv DOI: 10.1101/029496 (published DOI: 10.1534/g3.115.025668)

We describe a suite of predictive models, coined FASTmC, for non-reference, cost-effective exploration and comparative analysis of context-specific DNA methylation levels. Accurate estimations of true DNA methylation levels can be obtained from as few as several thousand short-reads generated from whole genome bisulfite sequencing. These models make high-resolution time course or developmental, and large diversity studies practical regardless of species, genome size and availability of a reference genome.

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