Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,466 bioRxiv papers from 297,269 authors.
In certain plant hybrids, autoimmunity is triggered by immune components that interact in the absence of a pathogen trigger. Often, NLR immune receptors are involved, with a particularly interesting case in Arabidopsis thaliana involving variants of the NLR RPP7 as well as variants of RPW8/HR proteins, which are homologs of animal MLKL and fungal HELL domain proteins. We demonstrate that HR4Fei-0 but not the closely related HR4Col-0 protein directly disrupts intramolecular association of RPP7bLerik1-3, which in turn initiates P-loop dependent NLR signaling. In agreement, RPP7bLerik1-3 forms a higher-order complex only in the presence of HR4Fei-0 but not HR4Col-0. In addition, we find that HR4Fei-0 on its own can form detergent-resistant oligomers suggestive of amyloid-like aggregates, which in turn can directly kill cells in an RPP7bLerik1-3-independent manner. Our work provides in vivo biochemical evidence for a plant resistosome complex and the mechanisms by which RPW8/HR proteins trigger cell death.
- Downloaded 591 times
- Download rankings, all-time:
- Site-wide: 17,096 out of 67,466
- In plant biology: 411 out of 1,957
- Year to date:
- Site-wide: 4,938 out of 67,466
- Since beginning of last month:
- Site-wide: 6,751 out of 67,466
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!