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Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine

By Sigrid Gouma, Madison Weirick, Scott E. Hensley

Posted 24 Jun 2019
bioRxiv DOI: 10.1101/681734 (published DOI: 10.1093/cid/ciz723)

Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.

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