Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,789 bioRxiv papers from 265,997 authors.

Higher fitness yeast genotypes are less robust to deleterious mutations

By Milo S. Johnson, Alena Martsul, Sergey Kryazhimskiy, Michael M Desai

Posted 20 Jun 2019
bioRxiv DOI: 10.1101/675314

Natural selection drives populations towards higher fitness, but second-order selection for adaptability and mutational robustness can also influence the dynamics of adaptation. In many microbial systems, diminishing returns epistasis contributes to a tendency for more-fit genotypes to be less adaptable, but no analogous patterns for robustness are known. To understand how robustness varies across genotypes, we measure the fitness effects of hundreds of individual insertion mutations in a panel of yeast strains. We find that more-fit strains are less robust: they have distributions of fitness effects (DFEs) with lower mean and higher variance. These shifts in the DFE arise because many mutations have more strongly deleterious effects in faster-growing strains. This negative correlation between fitness and robustness implies that second-order selection for robustness will tend to conflict with first-order selection for fitness.

Download data

  • Downloaded 459 times
  • Download rankings, all-time:
    • Site-wide: 19,468 out of 57,789
    • In evolutionary biology: 1,476 out of 3,967
  • Year to date:
    • Site-wide: 4,206 out of 57,789
  • Since beginning of last month:
    • Site-wide: 4,010 out of 57,789

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)