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Tuberculosis treatment outcome: The case of women in Ethiopia and China, Ten-Years Retrospective Cohort study

By Gebremeskel Mirutse, Mingwang Fang, Alemayehu Bayray kahsay, Xiao Ma

Posted 19 Jun 2019
bioRxiv DOI: 10.1101/676924

Every year tuberculosis kills above half million women all over the world. Nonetheless, the difference in the size of deaths among countries was not compared. Hence, this study is aimed to compare the death size of two countries. Socio demographic and clinical data of women treated for all form of tuberculosis in the past ten years 2007-2016 were collected from total of eight hospitals and six treatment centers of Tigray and Zigong respectively. Then, collected data were entered into SPSS version 21 then we estimated the magnitude of TB, level of treatment success and assessed factors associated with the unsuccessful TB outcome. In the past ten years, a total of 5603(41.5%) and 4527 (24.5%) tuberculosis cases were observed in Tigray and Zigong respectively. Of those with treatment outcome record a total of 2602(92%) in Tigray and 3916(96.7%) in Zigong were successfully treated. Total of 170 (6%) cases in Tigray and 36(0.8%) cases in Zigong were dead. In Tigray cases like retreatment (aOR, 0.29; 95% CI: 0.16-0.53) and multi drug resistant (aOR, 0.31; 95% CI: 0.003, 0.27) were less likely to show treatment success. But, HIV co-infected TB cases (aOR, 3.58; 95% CI: 2.47, 5.18) were more likely to show treatment success. In Zigong, women with MDR TB (Adjusted OR, 0.90; 95%CI: 0.24, 0.34) were less likely to show treatment success. On the other hand women in the age category of 15-49 (adjusted OR, 1.55; 95% CI: 1.08, 2.206) showed treatment success. Big number of tuberculosis cases and death were observed in Tigray comparing with Zigong. Hence, a relevant measure should be considered to improve treatment outcome of women in Tigray.

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