Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 64,897 bioRxiv papers from 287,634 authors.

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes and lipid species. We performed a review of all genetic association studies, and identified > 800 class-specific metabolite loci that influence metabolite levels. In a twin-family cohort ( N = 5,117), these metabolite loci were leveraged to simultaneously estimate total heritability ( h 2 total ), and the proportion of heritability captured by known metabolite loci ( h [2][1] Metabolite-hits ) for 309 lipids and 52 organic acids. Our study revealed significant differences in h 2 Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation had higher h 2 Metabolite-hits estimates than phosphatidylcholines with a low degree of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes and lipid species. [1]: #ref-2

Download data

  • Downloaded 474 times
  • Download rankings, all-time:
    • Site-wide: 21,379 out of 64,897
    • In genetics: 1,434 out of 3,681
  • Year to date:
    • Site-wide: 6,130 out of 64,897
  • Since beginning of last month:
    • Site-wide: 1,522 out of 64,897

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News