Rxivist logo

Pre-existent adult sox10+ cardiomyocytes contribute to myocardial regeneration in the zebrafish

By Marcos Sande-Melón, Ines J Marques, María Galardi-Castilla, Xavier Langa, María Pérez-López, Marius Botos, Gabriela Guzmán-Martínez, David Miguel Ferreira-Francisco, Dinko Pavlinic, Vladimit Benes, Remy Bruggmann, Nadia Mercader

Posted 07 Jun 2019
bioRxiv DOI: 10.1101/662536

During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from pre-existing ones. It is unclear whether the heart is comprised of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identified a subset of pre-existent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded massively after cryoinjury. Genetic ablation of sox10+ cardiomyocytes severely impaired cardiac regeneration revealing that they play a crucial role for heart regeneration.

Download data

  • Downloaded 707 times
  • Download rankings, all-time:
    • Site-wide: 49,158
    • In developmental biology: 1,103
  • Year to date:
    • Site-wide: 98,913
  • Since beginning of last month:
    • Site-wide: 152,318

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News