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Pre-existent adult sox10+ cardiomyocytes contribute to myocardial regeneration in the zebrafish

By Marcos Sande-Melón, Ines J Marques, María Galardi-Castilla, Xavier Langa, María Pérez-López, Marius Botos, Gabriela Guzmán-Martínez, David Miguel Ferreira-Francisco, Dinko Pavlinic, Vladimit Benes, Remy Bruggmann, Nadia Mercader

Posted 07 Jun 2019
bioRxiv DOI: 10.1101/662536

During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from pre-existing ones. It is unclear whether the heart is comprised of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identified a subset of pre-existent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded massively after cryoinjury. Genetic ablation of sox10+ cardiomyocytes severely impaired cardiac regeneration revealing that they play a crucial role for heart regeneration.

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