Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,313 bioRxiv papers from 263,927 authors.
Normal calcium responses to hormones and neurotransmitters are critical for neuronal health. Calcium responses are carried out by the Gαq/phospholipase Cβ (PLCβ )/ phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) signaling pathway. Here, we show that Gαq stimulation results in the retraction of neurites in PC12 cells and rupture of neuronal synapses. To understand the underlying cause, we dissected the behavior of individual components of the Gαq/PLCβ /PI(4,5)P2 pathway during retraction, and correlated these to the retraction of the membrane and cytoskeletal elements impacted by calcium signaling. We developed a mathematical model that combines biochemical signaling with membrane tension and cytoskeletal mechanics, to show how signaling events are coupled to retraction velocity, membrane tension and actin dynamics. The coupling between calcium and neurite retraction is shown to be operative in the C. elegans nervous system. This study uncovers a novel mechanochemical connection between the Gαq/PLCβ /PI(4,5)P2 pathway that couples calcium responses with neural plasticity.
- Downloaded 98 times
- Download rankings, all-time:
- Site-wide: 52,303 out of 57,313
- In biophysics: 2,223 out of 2,430
- Year to date:
- Site-wide: 32,314 out of 57,313
- Since beginning of last month:
- Site-wide: 23,146 out of 57,313
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!