Rxivist logo

We report a sensitive PCR-based assay that can detect aneuploidy in samples containing as little as 3 picograms of DNA. Using a single primer pair, we amplified ~750,000 amplicons distributed throughout the genome. Aneuploidy was detected in 49% of liquid biopsies from a total of 883 non-metastatic cancers of eight different types. Combining aneuploidy with somatic mutation detection and eight standard protein biomarkers yielded a median sensitivity of 80% at 99% specificity.

Download data

  • Downloaded 859 times
  • Download rankings, all-time:
    • Site-wide: 29,899
    • In cancer biology: 778
  • Year to date:
    • Site-wide: 111,774
  • Since beginning of last month:
    • Site-wide: 138,571

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News