Assessing aneuploidy with repetitive element sequencing.
Joshua D Cohen,
Robert E. Schoen,
Christopher L. Wolfgang,
Anne Marie Lennon,
Ralph H. Hruban,
Kenneth W Kinzler,
Posted 05 Jun 2019
bioRxiv DOI: 10.1101/660258 (published DOI: 10.1073/pnas.1910041117)
Posted 05 Jun 2019
We report a sensitive PCR-based assay that can detect aneuploidy in samples containing as little as 3 picograms of DNA. Using a single primer pair, we amplified ~750,000 amplicons distributed throughout the genome. Aneuploidy was detected in 49% of liquid biopsies from a total of 883 non-metastatic cancers of eight different types. Combining aneuploidy with somatic mutation detection and eight standard protein biomarkers yielded a median sensitivity of 80% at 99% specificity.
- Downloaded 859 times
- Download rankings, all-time:
- Site-wide: 29,899
- In cancer biology: 778
- Year to date:
- Site-wide: 111,774
- Since beginning of last month:
- Site-wide: 138,571
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!