MALT1 mediates IL-17 Neural Signaling to regulate C. elegans behavior, immunity and longevity
Sean M. Flynn,
Geoffrey M Nelson,
J. Mark Skehel,
Mario de Bono
Posted 03 Jun 2019
bioRxiv DOI: 10.1101/658617 (published DOI: 10.1038/s41467-020-15872-y)
Posted 03 Jun 2019
Besides well-known immune roles, the evolutionarily ancient cytokine interleukin-17 (IL-17) modulates neural circuit function. We investigate how IL-17 signals in neurons, and the extent to which this signaling can alter organismal phenotypes. We combine immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexes that function downstream of IL-17 receptors in C. elegans (Ce) neurons. We identify the Ce ortholog of MALT1 as a critical output of the pathway. MALT1 was not previously implicated in IL-17 signaling or in nervous system function. MALT1 forms a complex with homologs of Act1 and IRAK and functions both as a scaffold for IκB recruitment, and as a protease. MALT1 is expressed broadly in the Ce nervous system, and neuronal IL-17-MALT1 signaling regulates many phenotypes, including escape behavior, associative learning, immunity and longevity. Our data suggest MALT1 has an ancient role modulating neural function downstream of IL-17 to remodel physiological and behavioral state.
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