Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,182 bioRxiv papers from 306,477 authors.
Sleep, regional grey matter volumes, and psychological functioning in adolescents
Anna S. Urrila,
Arun L.W. Bokde,
Patricia J. Conrod,
Penny A. Gowland,
Michael N. Smolka,
Marie-Laure Paillère Martinot,
Posted 29 May 2019
bioRxiv DOI: 10.1101/645184
Posted 29 May 2019
Changing sleep rhythms in adolescents often lead to sleep deficits and increased variability in sleep schedules. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n=101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationship between regional grey matter volumes with psychological functioning. Sleep was assessed with self-reports and psychological functioning with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and both externalising and internalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development. * (AAL) : Anatomical Automatic Labeling; (AUDIT) : Alcohol Use Disorders Identification Test; (CANTAB) : Cambridge Automated Neuropsychological Test Battery; (FWE) : Family Wise Error; (MPRAGE) : Magnetisation Prepared Rapid Acquisition Gradient Echo; (mPFC) : Medial Prefrontal Cortex; (MNI) : Montreal Neurologic Institute; (fMRI) : functional Magnetic Resonance Imaging; (ROI) : Region Of Interest; (SPM) : Statistical Parametric Mapping; (SDQ) : Strengths and Difficulties Questionnaire; (VBM) : Voxel-Based Morphometry; (WD) : Weekday; (WE) : Weekend;
- Downloaded 248 times
- Download rankings, all-time:
- Site-wide: 44,686 out of 70,182
- In neuroscience: 7,879 out of 12,621
- Year to date:
- Site-wide: 8,226 out of 70,182
- Since beginning of last month:
- Site-wide: 6,347 out of 70,182
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!