Age-dependent sexual dimorphism in the adult human gut microbiota
By
Xiuying Zhang,
Huanzi Zhong,
Yufeng Li,
Zhun Shi,
Zhe Zhang,
Xianghai Zhou,
Huahui Ren,
Shanmei Tang,
Xueyao Han,
Yuxiang Lin,
Dan Wang,
Fangming Yang,
Chao Fang,
Zuodi Fu,
Lianying Wang,
Shida Zhu,
Yong Hou,
Xun Xu,
Huanming Yang,
Jian Wang,
Karsten Kristiansen,
Junhua LI,
Linong Ji
Posted 24 May 2019
bioRxiv DOI: 10.1101/646620
A decade of studies has established the importance of the gut microbiome in human health. In spite of sex differences in the physiology, lifespan, and prevalence of many age-associated diseases, sex and age disparities in the gut microbiota have been little studied. Here we show age-related sex differences in the adult gut microbial composition and functionality in two community-based cohorts from Northern China and the Netherlands. Consistently, women harbour a more diverse and stable microbial community across broad age ranges, whereas men exhibit a more variable gut microbiota strongly correlated with age. Reflecting the sex-biased age-gut microbiota interaction patterns, sex differences observed in younger adults are considerably reduced in the elderly population. Our findings highlight the age- and sex-biased differences in the adult gut microbiota across two ethnic population and emphasize the need for considering age and sex in studies of the human gut microbiota.
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