Rxivist logo

Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ESCC genome and two-thirds occur in long non-coding (lnc)RNA regions. DNA methylation and epigenetic heterogeneity both coincide with chromosomal topological alterations. Gene body methylation, polycomb repressive complex occupancy, and CTCF binding sites associate with cancer-specific gene regulation. Epigenetically-mediated activation of non-canonical WNT signaling and the lncRNA ESCCAL-1 were validated as potential ESCC driver alterations. Gene-specific cancer driver roles of epigenetic alterations and heterogeneity are identified.

Download data

  • Downloaded 608 times
  • Download rankings, all-time:
    • Site-wide: 60,032
    • In cell biology: 2,617
  • Year to date:
    • Site-wide: 49,597
  • Since beginning of last month:
    • Site-wide: 152,062

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide