Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,043 bioRxiv papers from 295,115 authors.

Cholinergic modulation of dentate gyrus processing through dynamic reconfiguration of inhibitory circuits

By Mora B Ogando, Noel Federman, Sebastián A. Romano, Luciano A Brum, Guillermo M Lanuza, Damian Refojo, Antonia Marin-Burgin

Posted 09 May 2019
bioRxiv DOI: 10.1101/632497

The dentate gyrus (DG) of the hippocampus plays a key role in memory formation and it is known to be modulated by septal projections. By performing electrophysiology and optogenetics we evaluated the role of cholinergic modulation in the processing of afferent inputs in the DG. We showed that mature granule cells (GCs), but not adult-born immature neurons, have increased responses to afferent perforant path stimuli upon cholinergic modulation. This is due to a highly precise reconfiguration of inhibitory circuits, differentially affecting Parvalbumin and Somatostatin interneurons, resulting in a nicotinic-dependent feedforward perisomatic disinhibition of GCs. This circuit reorganization provides a mechanism by which mature GCs could escape the strong inhibition they receive, creating a window of opportunity for plasticity. Indeed, coincident activation of perforant path inputs with optogenetic release of Ach produced a long-term potentiated response in GCs, which could be crucial for the formation of memories.

Download data

  • Downloaded 247 times
  • Download rankings, all-time:
    • Site-wide: 41,926 out of 67,043
    • In neuroscience: 7,397 out of 12,017
  • Year to date:
    • Site-wide: 19,026 out of 67,043
  • Since beginning of last month:
    • Site-wide: 26,046 out of 67,043

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)