Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 52,519 bioRxiv papers from 243,473 authors.
The prefrontal cortex (PFC) is crucial for many cognitive functions. PFC individual neuron activity and ensemble oscillation dynamics have been linked to unique aspects of behavior. However, it remains largely unclear how different neuron types relate to oscillation features. To understand how excitatory and inhibitory neurons in PFC are coordinated by distinct oscillation signatures, we designed a 3-choice auditory discrimination task and used tetrode devices to examine individual PFC neuron activity and ensemble LFP oscillations in task performing mice. We found that PFC neurons and ensemble LFP oscillations exhibited complex sensory evoked responses that are context and task-progression dependent. While both excitatory and inhibitory neurons were transiently modulated at different phases of the task, inhibitory neurons were increasingly recruited as trial progressed compared to excitatory neurons. Inhibitory neurons in general showed higher spike-field coherence with LFP oscillations than excitatory neurons throughout the task period, first at higher frequencies at the beginning of the task, and then transitioned to lower frequencies in the middle of the task that sustained beyond task completion. Together, our results demonstrate that excitatory and inhibitory neurons selectively engage distinct oscillation dynamics during sensory discrimination in mice.
- Downloaded 98 times
- Download rankings, all-time:
- Site-wide: 47,322 out of 52,519
- In neuroscience: 8,273 out of 9,207
- Year to date:
- Site-wide: 22,267 out of 52,519
- Since beginning of last month:
- Site-wide: 4,286 out of 52,519
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!