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Predicting late-onset Alzheimer's disease from genomic data using deep neural networks

By Javier de Velasco Oriol, Edgar E. Vallejo, Karol Estrada, The Alzheimer’s Disease Neuroimaging Initiative

Posted 06 May 2019
bioRxiv DOI: 10.1101/629402

Alzheimer's disease (AD) is the leading form of dementia. Over 25 million cases have been estimated worldwide and this number is predicted to increase two-fold every 20 years. Even though there is a variety of clinical markers available for the diagnosis of AD, the accurate and timely diagnosis of this disease remains elusive. Recently, over a dozen of genetic variants predisposing to the disease have been identified by genome-wide association studies. However, these genetic variants only explain a small fraction of the estimated genetic component of the disease. Therefore, useful predictions of AD from genetic data could not rely on these markers exclusively as they are not sufficiently informative predictors. In this study, we propose the use of deep neural networks for the prediction of late-onset Alzheimer's disease from a large number of genetic variants. Experimental results indicate that the proposed model holds promise to produce useful predictions for clinical diagnosis of AD.

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