Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,143 bioRxiv papers from 295,510 authors.

Multi-trait genome-wide association meta-analysis of dietary intake identifies new loci and genetic and functional links with metabolic traits

By Jordi Merino, Hassan S Dashti, Chloé Sarnowski, Jacqueline M. Lane, Miriam S Udler, Petar V Todorov, Yanwei Song, Heming Wang, Jaegil Kim, Chandler Tucker, John Campbell, Toshiko Tanaka, Audrey Y Chu, Linus Tsai, Tune H. Pers, Daniel I Chasman, Josée Dupuis, Martin K. Rutter, Jose C Florez, Richa Saxena

Posted 01 May 2019
bioRxiv DOI: 10.1101/623728

Dietary intake, a major contributor to the global obesity epidemic, is a complex phenotype partially affected by innate physiological processes. However, previous genome-wide association studies (GWAS) have only implicated a few loci in variability of dietary composition. Here, we present a multi-trait genome-wide association meta-analysis of inter-individual variation in dietary intake in 283,119 European-ancestry participants from UK Biobank and CHARGE consortium, and identify 96 genome-wide significant loci. Dietary intake signals map to different brain tissues and are enriched for genes expressed in b1-tanycytes and serotonergic and GABAergic neurons. We also find enrichment of biological pathways related to neurogenesis. Integration of cell-line and brain-specific epigenomic annotations identify 15 additional loci. Clustering of genome-wide significant variants yields three main genetic clusters with distinct associations with obesity and type 2 diabetes (T2D). Overall, these results enhance biological understanding of dietary composition, highlight neural mechanisms, and support functional follow-up experiments.

Download data

  • Downloaded 289 times
  • Download rankings, all-time:
    • Site-wide: 37,324 out of 67,143
    • In genetics: 2,305 out of 3,776
  • Year to date:
    • Site-wide: 15,401 out of 67,143
  • Since beginning of last month:
    • Site-wide: 34,950 out of 67,143

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News