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TeraVR Empowers Precise Reconstruction of Complete 3-D Neuronal Morphology in the Whole Brain

By Yimin Wang, Qi Li, Lijuan Liu, Zhi Zhou, Yun Wang, Lingsheng Kong, Ning Zhong, Renjie Chai, Xiangfeng Luo, Yike Guo, Michael Hawrylycz, Qingming Luo, Zhongze Gu, Wei Xie, Hongkui Zeng, Hanchuan Peng

Posted 28 Apr 2019
bioRxiv DOI: 10.1101/621011 (published DOI: 10.1038/s41467-019-11443-y)

Neuron morphology is recognized as a key determinant of cell type, yet the quantitative profiling of a mammalian neuron's complete three-dimensional (3-D) morphology remains arduous when the neuron has complex arborization and long projection. Whole-brain reconstruction of neuron morphology is even more challenging as it involves processing tens of teravoxels of imaging data. Validating such reconstructions is extremely laborious. We developed TeraVR, an open-source virtual reality annotation system, to address these challenges. TeraVR integrates immersive and collaborative 3-D visualization, interaction, and hierarchical streaming of teravoxel-scale images. Using TeraVR, we produced precise 3-D full morphology of long-projecting neurons in whole mouse brains and developed a collaborative workflow for highly accurate neuronal reconstruction.

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