White matter microstructure and its relation to longitudinal measures of depressive symptoms in mid-late life
Background: Studies of white matter microstructure in depression typically show alterations in depressed individuals, but they are frequently limited by small sample sizes and the absence of longitudinal measures of depressive symptoms. Depressive symptoms are however dynamic, and understanding the neurobiology of different trajectories could have important clinical implications. Methods: We examined associations between current and longitudinal measures of depressive symptoms and white matter microstructure (Fractional Anisotropy, FA; Mean Diffusivity; MD) in the UK Biobank Imaging study. Depressive symptoms were assessed on 2-4 occasions over 5.9 to 10.7 years (on N=18,959 individuals on at least two occasions, N=4,444 on four occasions) from which we derived four measures of depressive symptomatology; (i) cross-sectional measure at the time of scan (imaging was conducted at a single time point), and three longitudinal measures, (ii) trajectory (iii) mean and (iv) intra-subject variance over time. Results: Decreased white matter microstructure in the anterior thalamic radiation demonstrated significant associations across all four measures of depressive symptoms (for MD: β=0.020 to 0.029, pcorr<0.030). The greatest effect sizes were however seen between decreasing white matter integrity and increasing longitudinal progression of symptoms (for MD: β=0.030 to 0.040, pcorr<0.049). Cross-sectional symptom severity was particularly associated with decreased white matter integrity in association fibres and thalamic radiations (MD: β=0.015 to 0.039, pcorr<0.041). While greater mean and within subject variance of depressive symptoms were mainly associated with decreased white matter microstructure within projection fibres (MD: β=0.019 to 0.029, pcorr<0.044). Conclusions: These findings indicate shared and differential neurobiological associations with severity, course and intra-subject variability of depressive symptoms. This enriches our understanding of the neurobiology underlying dynamic features of the disorder.
- Downloaded 143 times
- Download rankings, all-time:
- Site-wide: 74,905 out of 84,908
- In neuroscience: 13,440 out of 15,117
- Year to date:
- Site-wide: 81,566 out of 84,908
- Since beginning of last month:
- Site-wide: 78,143 out of 84,908
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!