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Probabilistic inference of bifurcations in single-cell data using a hierarchical mixture of factor analysers

By Kieran R Campbell, Christopher Yau

Posted 21 Sep 2016
bioRxiv DOI: 10.1101/076547 (published DOI: 10.1093/bioinformatics/btw798)

Modelling bifurcations in single-cell transcriptomics data has become an increasingly popular field of research. Several methods have been proposed to infer bifurcation structure from such data but all rely on heuristic non-probabilistic inference. Here we propose the first generative, fully probabilistic model for such inference based on a Bayesian hierarchical mixture of factor analysers. Our model exhibits competitive performance on large datasets despite implementing full MCMC sampling and its unique hierarchical prior structure enables automatic determination of genes driving the bifurcation process.

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