Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 60,222 bioRxiv papers from 267,720 authors.

INTRODUCTION: It is established that Alzheimers disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. METHODS: Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness) on AD risk. RESULTS: Overall, there was little evidence that sleep traits affect the risk of AD. There was some evidence to suggest that self-reported daytime napping was associated with lower AD risk (odds ratio [OR]: 0.70, 95% confidence interval [CI]: 0.50 to 0.99). Some other sleep traits (accelerometer-measured eveningness and sleep duration, and self-reported daytime sleepiness) had ORs for AD risk of a similar magnitude to daytime napping, but were less precisely estimated. DISCUSSON: Our findings provide tentative evidence that daytime napping may reduce AD risk. However, findings should be replicated using independent samples.

Download data

  • Downloaded 248 times
  • Download rankings, all-time:
    • Site-wide: 36,637 out of 60,222
    • In epidemiology: 626 out of 1,556
  • Year to date:
    • Site-wide: 13,247 out of 60,222
  • Since beginning of last month:
    • Site-wide: 20,414 out of 60,222

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)