Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 50,150 bioRxiv papers from 233,741 authors.
Nanoscale subcellular architecture revealed by multicolor 3D salvaged fluorescence imaging
Lena K. Schroeder,
Mark D. Lessard,
Pietro De Camilli,
James E Rothman,
Posted 18 Apr 2019
bioRxiv DOI: 10.1101/613174
Posted 18 Apr 2019
Combining the molecular specificity of fluorescent probes with three-dimensional (3D) imaging at nanoscale resolution is critical for investigating the spatial organization and interactions of cellular organelles and protein complexes. We present a super-resolution light microscope that enables simultaneous multicolor imaging of whole mammalian cells at ~20 nm 3D resolution. We show its power for cell biology research with fluorescence images that resolved the highly convoluted Golgi apparatus and the close contacts between the endoplasmic reticulum and the plasma membrane, structures that have traditionally been the imaging realm of electron microscopy.
- Downloaded 960 times
- Download rankings, all-time:
- Site-wide: 5,838 out of 50,150
- In biophysics: 157 out of 2,112
- Year to date:
- Site-wide: 506 out of 50,150
- Since beginning of last month:
- Site-wide: 78 out of 50,150
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!