Rxivist logo

Quantitative proteomic alterations of human iPSC-based neuronal development indicate early onset of Rett syndrome.

By Suzy Varderidou-Minasian, Lisa Hinz, Dominique Hagemans, Danielle Posthuma, Maarten Altelaar, Vivi M. Heine

Posted 10 Apr 2019
bioRxiv DOI: 10.1101/603647

Rett syndrome (RTT) is a progressive neurodevelopmental disease often caused by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). The mechanisms by which impaired MeCP2 induces the pathological abnormalities in the brain is not understood. To understand the molecular mechanisms involved in disease onset, we used an RTT patient induced pluripotent stem cell (iPSC)-based model and applied an in-depth high-resolution quantitative mass spectrometry-based analysis during early stages of neuronal development. Our data provided evidence of proteomic alteration at developmental stages long before the phase that symptoms of RTT syndrome become apparent. Differential expression increased from early to late neural stem cell phases, although proteins involved in immunity, metabolic processes and calcium signaling were already affected at initial stages. This data can help development of new biomarkers and therapeutic approaches in RTT syndrome.

Download data

  • Downloaded 441 times
  • Download rankings, all-time:
    • Site-wide: 36,155 out of 88,857
    • In neuroscience: 6,224 out of 15,814
  • Year to date:
    • Site-wide: 24,972 out of 88,857
  • Since beginning of last month:
    • Site-wide: 54,470 out of 88,857

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News