Non-Linear Realignment Improves Hippocampus Subfield Segmentation
Thomas B Shaw,
Nicole T Atcheson,
Posted 05 Apr 2019
bioRxiv DOI: 10.1101/597856 (published DOI: 10.1016/j.neuroimage.2019.116206)
Posted 05 Apr 2019
Participant movement can deleteriously affect MR image quality. Further, for the visualization and segmentation of small anatomical structures, there is a need to improve image quality, specifically signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), by acquiring multiple anatomical scans consecutively. We aimed to ameliorate movement artefacts and increase SNR in a high-resolution turbo spin-echo (TSE) sequence acquired thrice using non-linear deformations in order to improve segmentation consistency of the hippocampus subfields. We assessed the method in young healthy participants, Motor Neurone Disease patients, and age matched healthy controls. Results show improved image segmentation of the hippocampus subfields when comparing template-based segmentations with individual segmentations N=51; ps < 0.001 (Friedman's test) and higher sharpness ps < 0.001 in non-linearly realigned scans as compared to linearly, and arithmetically averaged scans.
- Downloaded 325 times
- Download rankings, all-time:
- Site-wide: 92,020
- In neuroscience: 13,966
- Year to date:
- Site-wide: 123,847
- Since beginning of last month:
- Site-wide: None
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!