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Optimized implementations of voxel-wise degree centrality and local functional connectivity density mapping in AFNI

By R Cameron Craddock, Daniel J. Clark

Posted 05 Aug 2016
bioRxiv DOI: 10.1101/067702 (published DOI: 10.1186/s13742-016-0147-0-d)

Degree centrality (DC) and local functional connectivity density (lFCD) are statistics calculated from brain connectivity graphs that measure how important a brain region is to the graph. DC (a.k.a. global functional connectivity density) is calculated as the number of connections a region has with the rest of the brain (binary DC), or the sum of weights for those connections (weighted DC). lFCD was developed to be a surrogate measure of DC that is faster to calculate by restricting its computation to regions that are spatially adjacent. Although both of these measures are popular for investigating inter-individual variation in brain connectivity, efficient neuroimaging tools for computing them are scarce. The goal of this Brainhack project was to contribute optimized implementations of these algorithms to the widely used, open source, AFNI software package.

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