Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 53,026 bioRxiv papers from 245,564 authors.
Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome
Jennifer B Spagnolo,
Stephany Flores Ramos,
Kenji L Kurita,
Allyson L Byrd,
Alexander A. Aksenov,
Alexey V Melnik,
Weng R Wong,
Ryan D. Hernandez,
Mohamed S. Donia,
Pieter C Dorrestein,
Heidi H Kong,
Julia A Segre,
Roger G Linington,
Michael A Fischbach,
Katherine P Lemon
Posted 30 Mar 2019
bioRxiv DOI: 10.1101/594010
Posted 30 Mar 2019
The composition of the skin microbiome varies widely among individuals sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin. We used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes) that is widely distributed across individuals and skin sites. Experimental characterization of this cluster enabled the identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles showed that cutimycin is an important factor regulating colonization resistance against Staphylococcus species.
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