Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,481 bioRxiv papers from 319,807 authors.

Hierarchy of connectivity-function relationship of the human cortex revealed through predicting activity across functional domains

By Dongya Wu, Lingzhong Fan, Ming Song, Haiyan Wang, Congying Chu, Shan Yu, Tianzi Jiang

Posted 28 Mar 2019
bioRxiv DOI: 10.1101/591776

Many studies showed that anatomical connectivity supports both anatomical and functional hierarchies that span across the primary and association cortices in the cerebral cortex. However, it remains unclear whether a hierarchy of connectivity-function relationship (CFR) exists across the human cortex as well as how to characterize the hierarchy of this CFR if it exists. We first addressed whether anatomical connectivity could be used to predict functional activations across different functional domains using multilinear regression models. Then we characterized the CFR by predicting activity from anatomical connectivity throughout the cortex. We found that there is a hierarchy of CFR across the human cortex. Moreover, this CFR hierarchy was correlated to the functional and anatomical hierarchy reflected in functional flexibility, functional variability, and the myelin map. Our results suggest a shared hierarchical mechanism in the cortex, a finding which provides important insights into the anatomical and functional organization of the human brain.

Download data

  • Downloaded 350 times
  • Download rankings, all-time:
    • Site-wide: 35,769 out of 73,481
    • In neuroscience: 6,238 out of 13,211
  • Year to date:
    • Site-wide: 55,140 out of 73,481
  • Since beginning of last month:
    • Site-wide: 55,140 out of 73,481

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)