Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,143 bioRxiv papers from 295,399 authors.

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

By Anna J Stevenson, Daniel L McCartney, Robert F Hillary, Paul Redmond, Adele M. Taylor, Qian Zhang, Allan F. McRae, Tara L Spires-Jones, Andrew M McIntosh, Ian J Deary, Riccardo E Marioni

Posted 25 Mar 2019
bioRxiv DOI: 10.1101/588293

The identification of biomarkers that discriminate individual ageing trajectories is a principal target in ageing research. Some of the most promising predictors of biological ageing have been developed using DNA methylation. One recent candidate, which tracks age-related phenotypes in addition to chronological age, is 'DNAm PhenoAge'. Here, we performed a phenome-wide association analysis of this biomarker in a cohort of older adults to assess its relationship with a comprehensive set of both historical and contemporaneously-measured phenotypes. Higher than expected DNAm PhenoAge compared to chronological age, known as epigenetic age acceleration, was found to associate with a number of blood, cognitive, physical fitness and lifestyle variables, and with mortality. Notably, DNAm PhenoAge, assessed at age 70, was associated with cognitive ability at age 11, and with educational attainment. Adjusting for age 11 cognitive ability attenuated the majority of the cross-sectional later-life associations between DNAm PhenoAge and health outcomes. These results highlight the importance of early-life factors on healthy ageing.

Download data

  • Downloaded 308 times
  • Download rankings, all-time:
    • Site-wide: 35,382 out of 67,143
    • In genomics: 3,288 out of 4,562
  • Year to date:
    • Site-wide: 14,079 out of 67,143
  • Since beginning of last month:
    • Site-wide: 37,385 out of 67,143

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News