Rxivist logo

A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems

By Jacob W. Vogel, Renaud La Joie, Michel J Grothe, Alex Diaz-Papkovich, J. Andrew Doyle, Etienne Vachon-Presseau, Claude Lepage, Reinder Vos de Wael, Yasser Iturria-Medina, Boris Bernhardt, Gil D. Rabinovici, Alan C. Evans

Posted 24 Mar 2019
bioRxiv DOI: 10.1101/587071 (published DOI: 10.1038/s41467-020-14518-3)

The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the hippocampus can be predicted within 2mm using the expression pattern of less than 100 genes. When variation in this specific gene expression pattern was observed across the whole-brain, a distinct anterioventral-posteriodorsal gradient was observed. Frontal, anterior temporal and brainstem regions involved in social and motivational behaviors, selectively vulnerable to frontotemporal dementia and more functionally connected to the anterior hippocampus could be clearly differentiated from posterior parieto-occipital and cerebellar regions involved in spatial cognition, selectively vulnerable to Alzheimer's disease, and more functionally connected to the posterior hippocampus. These findings place the human hippocampus at the interface of two major brain systems defined by a distinct molecular gradient.

Download data

  • Downloaded 1,006 times
  • Download rankings, all-time:
    • Site-wide: 12,430 out of 100,334
    • In neuroscience: 1,976 out of 17,859
  • Year to date:
    • Site-wide: 30,414 out of 100,334
  • Since beginning of last month:
    • Site-wide: None out of 100,334

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News

  • 20 Oct 2020: Support for sorting preprints using Twitter activity has been removed, at least temporarily, until a new source of social media activity data becomes available.
  • 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
  • 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
  • 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
  • 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
  • 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
  • 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
  • 22 Jan 2019: Nature just published an article about Rxivist and our data.
  • 13 Jan 2019: The Rxivist preprint is live!