Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,313 bioRxiv papers from 263,927 authors.

THE HIDDEN REPERTOIRE OF BRAIN DYNAMICS AND DYSFUNCTION

By Randy McIntosh, Viktor Jirsa

Posted 16 Mar 2019
bioRxiv DOI: 10.1101/578443

The purpose of this paper is to describe a framework for the understanding of rules that govern how neural system dynamics are coordinated to produce behavior. The framework, structured flows on manifolds (SFM), posits that neural processes are flows depicting system interactions that occur on relatively low-dimension manifolds, which constrain possible functional configurations. Although this is a general framework, we focus on the application to brain disorders. We first explain the Epileptor, a phenomenological computational model showing fast and slow dynamics, but also a hidden repertoire whose expression is similar to refractory status epilepticus. We suggest that epilepsy represents an innate brain state whose potential may be realized only under certain circumstances. Conversely, deficits from damage or disease processes, such as stroke or dementia, may reflect both the disease process per se and the adaptation of the brain. SFM uniquely captures both scenarios.

Download data

  • Downloaded 804 times
  • Download rankings, all-time:
    • Site-wide: 9,092 out of 57,313
    • In neuroscience: 1,411 out of 10,055
  • Year to date:
    • Site-wide: 1,535 out of 57,313
  • Since beginning of last month:
    • Site-wide: 5,724 out of 57,313

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News