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WinnerTakeAlmostAll: A parsimony approach integrating multi-targets improves marker gene profiling

By Zewei Song, Xiaohuan Sun, Zhongkui Xia, Yangyang Jia, Zhu Jie, Chao Fang, Huanming Yang, Jian Wang

Posted 12 Mar 2019
bioRxiv DOI: 10.1101/575100

Amplicon sequencing need to go from using single region to multiple region, one for higher resolution, one for technical replicates. WinnerTakeAlmostAll is an algorithm to calculate a minimum set of references based on the reference-query graph. We showed that this algorithm is superior in resolving species, as well as average out the run effect using technical replicates.

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