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deStruct: Accurate Rearrangement Detection using Breakpoint Specific Realignment

By Andrew McPherson, Sohrab P Shah, S. Cenk Sahinalp

Posted 18 Mar 2017
bioRxiv DOI: 10.1101/117523

We propose that a breakpoint specific alignment procedure would improve breakpoint prediction. Our method, deStruct, uses multiple stages of realignment and clustering to progressively refine breakpoint prediction quality and accuracy. We show using simulated data that deStruct predicts breakpoints with higher sensitivity and specificity than existing breakpoint prediction tools.

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