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A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population

By Samira Asgari, Yang Luo, Gillian M Belbin, Eric Bartell, Roger Calderon, Dorothee Diogo, Carmen Contreras, Rosa Yataco, Jerome Galea, Judith Jimenez, Julia M. Coit, Chandel Farroñay, Rosalynn M. Nazarian, Timothy D. O’Connor, Harry C. Dietz, Joel Hirschhorn, Heinner Guio, Leonid Lecca, Eimear E Kenny, Esther Freeman, Megan B Murray, Gosia Trynka

Posted 26 Feb 2019
bioRxiv DOI: 10.1101/561241

Peruvians are among the shortest people in the world. To understand the genetic basis of short stature in Peru, we examined an ethnically diverse group of Peruvians and identified a novel, population-specific, missense variant in FBN1 (E1297G) that is significantly associated with lower height in the Peruvian population. Each copy of the minor allele (frequency = 4.7%) reduces height by 2.2 cm (4.4 cm in homozygous individuals). This is the largest effect size known for a common height-associated variant. This variant shows strong evidence of positive selection within the Peruvian population and is significantly more frequent in Native American populations from coastal regions of Peru compared to populations from the Andes or the Amazon, suggesting that short stature in Peruvians is the result of adaptation to the coastal environment.

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